CD4+ T cell–independent DNA vaccination against opportunistic infections
J. Clin. Invest. Mingquan Zheng, et al. 115:3536 doi:10.1172/JCI26306 [
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Figure 3Antigen-specific CD8
+ T cell responses. SIINFEKL-specific CD8
+ T cell responses in CD4-depleted (
A) and CD4-replete (
B) mice after OVA and OVA/CD40L prime-boost regimens.
n = 3–4 per group. *
P < 0.05 compared with no-boost control. (
C) IFN-γ secretion determined by ELISA in OVA-stimulated CD8
+ T cells from both CD4-replete and CD4-depleted mice.
n = 3–4 per group. *
P < 0.05 compared with pOVA control. All data are mean values ± SEM.
