Decreased vascular lesion formation in
mice with inducible endothelial-specific expression of protein kinase Akt
J. Clin. Invest. Yasushi Mukai, et al. 116:334 doi:10.1172/JCI26223 [
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Figure 2Endothelial NO production and bioactivity in EC-Akt Tg mice. (
A) NO production in MLECs from induced EC-Akt Tg mice. Nitrite (NO
2) was measured in ECs under serum-starved conditions with or without myrAkt transgene induction. Results are expressed as mean ± SEM.
n = 8 in each group. **
P < 0.01 versus cells without gene induction. (
B) Force measurement in isolated mouse aorta. Endothelial-dependent contractions in response to
L-NAME were determined. Results are expressed as mean ± SEM.
n = 6 in each group. *
P < 0.05 versus WT.
