Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis
J. Clin. Invest. Kimberly A. Risma, et al. 116:182 doi:10.1172/JCI26217 [Go to this article.]

Figure 3
Lytic function of perforin expressed in RBL-1 and RBL-2H3 cells. (A) Perforin-dependent ⁵¹Cr release from TNP-treated rbcs coincubated for 4 hours with RBL cells, in the presence or absence (–IgE) of anti–2,4-dinitrophenol IgE. Human and mouse perforin exhibited lytic activity after degranulation of RBL-2H3 cells. (B) In contrast, degranulation of RBL-1 cells expressing human perforin did not lead to rbc lysis. E/T, effector/target.