Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia
J. Clin. Invest. Marinella Pirozzi, et al. 116:202 doi:10.1172/JCI26210 [
Go to this article.]
Figure 4Rescue of the neuropathological phenotype in the peripheral nerve. (
A–
D) Semithin sections of the distal sciatic nerves in 16-month-old
Spg7–/– mice. Six months before the neuropathological studies, mice were treated with a single intramuscular injection of AAV-LacZ on the left side (
A and
C) and either AAV2/1-Spg7 (
B) or AAV2/2-Spg7 (
D) on the right side. Note the decreased number of affected axons (arrows) in the nerves from the side treated with the Spg7 vectors. (
E) Morphometric quantification of the percentage of affected axons for animals treated with AAV2/1 and AAV2/2 vectors. The
P value of Student’s
t test is shown. Scale bar: 15 μm (
A–
D).
