Intramuscular viral delivery of paraplegin rescues peripheral axonopathy in a model of hereditary spastic paraplegia
J. Clin. Invest. Marinella Pirozzi, et al. 116:202 doi:10.1172/JCI26210 [Go to this article.]

Figure 2
Retrograde transduction of spinal motor neurons by AAV vectors. Expression of β-gal activity in the skeletal muscle (A) and spinal cord (B) 4 weeks after injection of different AAV-LacZ vector serotypes in the gastrocnemius muscle. (A) AAV2/1 shows remarkable transduction of skeletal muscle, followed by AAV2/7 and AAV2/5. Conversely, the muscle transduction level for AAV2/2 and AAV2/8 is low. (B) Longitudinal sections of lumbar spinal cord to visualize targeting of motor neurons by retrograde transport of AAV (left side injected with AAV-LacZ). β-Gal activity restricted to motor neurons is visible only with AAV2/2 and AAV2/1. Magnification, ×10.