The H1 histamine receptor regulates allergic lung responses
J. Clin. Invest. Paul J. Bryce, et al. 116:1624 doi:10.1172/JCI26150 [Go to this article.]

Figure 6
H1R^–/– T cells do not migrate into the lung following antigen challenge. Thy1 congenic antigen-expanded CD4⁺ T cells (A) or CD3⁺ T cells (B) from WT or H1R^–/– mice were adoptively transferred into naive WT or H1R^–/– recipients. Cells were adoptively transferred into naive recipients and their movement into spleen, whole lung tissue, and BAL fluid studied. Single-cell suspensions were stained using FITC-Thy1.1 or FITC-Thy1.2 (see Methods) and PE-CD4 or PE-CD8 to determine the presence of the transferred cells. The plots shown were obtained by analysis of the pooled cells of 5 animals of each group and represent 3 individual experiments.