Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
J. Clin. Invest. Marco Prinz, et al. 116:456 doi:10.1172/JCI26078 [Go to this article.]

Figure 5
Encephalitogenic T cells are less effective at inducing EAE when transferred into MyD88- or TLR9-deficient hosts. Adoptive transfer of MOG-reactive T cells (25 × 10⁶ cells) into MyD88^–/– or TLR9^–/– but not TLR2^–/– hosts results in milder disease. Data shown are from 1 representative experiment of at least 2 individual experiments with at least 5 mice per group (means). Asterisks indicate statistical significance. P < 0.05.