Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
J. Clin. Invest. Marco Prinz, et al. 116:456 doi:10.1172/JCI26078 [
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Figure 1TLR regulation during autoimmune CNS disease. Expression of TLRs and MyD88 in the CNS of EAE-diseased mice. TLR1–9 and MyD88 mRNA were detected in spinal cord tissue samples by using real-time PCR at different stages of disease. Immunized, nonsick animals (score 0) are indicated in white, slightly diseased mice (score 0.5–1.5) in black, and mice with severe EAE (score > 2.5) in gray. Data are expressed as ratio of induced TLR to endogenous GAPDH and expressed as SEM.
