Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
J. Clin. Invest. Aimee M. Powelka, et al. 116:125 doi:10.1172/JCI26040 [
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Figure 9Absence of RIP140 protects against age- and diet-induced glucose intolerance and enhances insulin responsiveness on a high-fat diet. Glucose tolerance tests were performed on 3-month-old female mice fed a normal chow diet (
A), 8-month-old female mice fed a normal chow diet (
B), or 3-month-old female mice fed a high-fat diet (
C) for 10 weeks. Values are mean ± SEM;
n = 6–12. (
D) Insulin tolerance tests were performed on 3-month-old female mice fed a high-fat diet for 9 weeks. Values are mean ± SEM;
n = 9.
