Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
J. Clin. Invest. Aimee M. Powelka, et al. 116:125 doi:10.1172/JCI26040 [
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Figure 6Metabolic and mitochondrial protein expression is enhanced in 3T3-L1 adipocytes depleted of RIP140. Eight days after the induction of differentiation, 3T3-L1 adipocytes were transfected with scrambled or RIP140 siRNA. After 72 hours, postnuclear supernatants were used for immunoblotting selected proteins in oxidative phosphorylation and fatty acid oxidation pathways. Shown is a representative blot and densitometric quantification of 3 independent experiments (mean ± SEM). All of the changes shown (except those for actin) were significant at
P < 0.05 (indicated by asterisk).
