Tbx18 regulates the development
of the ureteral mesenchyme
J. Clin. Invest. Rannar Airik, et al. 116:663 doi:10.1172/JCI26027 [
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Figure 5Molecular characterization of
Tbx18–/– ureteral mesenchyme. Whole-mount in situ hybridization analysis of mesenchymal marker genes in E12.5 kidneys and ureters (
A–
P). Arrows indicate ureteral mesenchyme. Insets in (
I–
P) show in situ hybridization analysis on transverse ureter sections.
Ptc1,
Patched1. The ureteric epithelium is shown by a black circle. In situ hybridization analysis of
Pod1 expression on transverse sections of E14.5 kidneys (
Q and
U) and ureters (
R and
V) and of
SM22α expression on transverse sections of E16.5 ureters (
S and
W). Arrowheads in
U indicate ectopic fibrous tissue connecting gonad and kidney. (
T and
X) Immunohistochemistry for α-SMA on transverse sections of E18.5 ureters. cs, cortical stroma; ms, medullary stroma; SML, smooth muscle layer. Scale bars: 100 μm, 120 μm (insets).
