Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice
J. Clin. Invest. David G. Motto, et al. 115:2752 doi:10.1172/JCI26007 [Go to this article.]

Figure 6
Spontaneous TTP in Adamts13^B/CN2–/– mice. (A) Peripheral blood smear showing thrombocytopenia, schistocytes, and fragmented rbc. (B–J) Tissue sections showing vWF-rich and fibrin-poor thrombi in small blood vessels from brain (B–D), heart (E–G), and kidney (H–J). Sections were stained with H&E (B, E, and H), anti-vWF (C, F, and I), or anti-fibrinogen (D, G, and J). Difficult-to-visualize thrombi are indicated with arrows. Magnification, ×1,000 (A); and ×200 (B–J).