Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice
J. Clin. Invest. David G. Motto, et al. 115:2752 doi:10.1172/JCI26007 [Go to this article.]

Figure 4
Lack of TTP pathology in Adamts13^B/129–/– mice. (A and B) Peripheral blood smears from Adamts13^B/129+/+ (A) and Adamts13^B/129–/– (B) mice appear identical, without evidence of schistocytes, rbc fragments, thrombocytopenia, or nucleated rbc. (C–H) H&E–stained tissue sections from Adamts13^B/129+/+ (C, E, and G) and Adamts13^B/129–/– (D, F, and H) are indistinguishable, without evidence of the pink-staining “hyaline thrombi” typically seen in affected organs from humans with TTP. Representative sections are shown from kidney (C and D), brain (E and F), and heart (G and H). Magnification, ×1,000 (A and B); ×400 (C and D); ×100 (E and F); and ×200 (G and H).