Absence of ghrelin protects against
early-onset obesity
J. Clin. Invest. Katherine E. Wortley, et al. 115:3573 doi:10.1172/JCI26003 [
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Figure 3The GH/IGF-1 axis in 6-month-old male
Ghrl–/– mice fed a standard diet or HFD 3 weeks after weaning. (
A) Pituitary GH mRNA in
Ghrl+/+ and
Ghrl–/– mice on standard diet was similar, whereas on the HFD, GH mRNA was increased in
Ghrl–/– compared with
Ghrl+/+ mice (*
P < 0.05). (
B) IGF-1 mRNA in liver was similar in
Ghrl+/+ and
Ghrl–/– mice on the standard diet, whereas it showed a tendency to be increased in
Ghrl–/– mice compared with
Ghrl+/+ mice fed a HFD. (
C) GHR mRNA in the liver of
Ghrl+/+ and
Ghrl–/– mice on standard diet was similar, whereas on the HFD, GHR mRNA was increased in
Ghrl–/– mice compared with
Ghrl+/+ mice (*
P < 0.05).
n = 5–9/genotype.
