Absence of ghrelin protects against
early-onset obesity
J. Clin. Invest. Katherine E. Wortley, et al. 115:3573 doi:10.1172/JCI26003 [
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Figure 2Metabolic parameters in 18-week-old male
Ghrl–/– mice fed the standard diet or the HFD 3 weeks after weaning. RQs in male
Ghrl+/+ and
Ghrl–/– mice on the standard diet (
A) and HFD (
B) were similar. Energy expenditure in male
Ghrl+/+ and
Ghrl–/– mice on the standard diet (
C) was similar, whereas on the HFD (
D), energy expenditure was increased in
Ghrl–/– mice; repeated measures ANOVA, effect of genotype: F
(1, 14) = 5.062;
P < 0.05 (*
P < 0.05, post-hoc test). Locomotor activity was similar in male
Ghrl+/+ and
Ghrl–/– mice on the standard diet (
E), whereas activity was increased in male
Ghrl–/– mice fed the HFD (
F); *
P < 0.05. Gray bars represent the dark period.
n = 5–7/genotype for standard diet;
n = 8/genotype for HFD.
