Tlx acts as a proangiogenic switch
by regulating extracellular assembly
of fibronectin matrices in retinal astrocytes
J. Clin. Invest. Akiyoshi Uemura, et al. 116:369 doi:10.1172/JCI25964 [
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Figure 4Oxygen concentration synchronously controls expression of
Tlx and
VEGF but not
fibronectin in retinal astrocytes. Immunostaining for type IV collagen and ISH for
Tlx,
VEGF,
fibronectin, and
GFAP. Expression levels of
Tlx and
VEGF mRNA are dramatically downregulated under hyperoxic conditions (upper panels) whereas they are synchronously restored after the return to room air (lower panels). In contrast,
fibronectin expression is continuously maintained even under hyperoxia.
GFAP expression is not upregulated beyond the vascularized areas. Magnification, ×126.
