αB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer
J. Clin. Invest. Jose V. Moyano, et al. 116:261 doi:10.1172/JCI25888 [Go to this article.]

Figure 1
αB-Crystallin is expressed in the basal-like subtype of breast cancer and independently predicts shorter survival. (A) Expanded view of the basal epithelial gene expression cluster presented by Sorlie et al. (4) (red, above average gene expression; green, below average gene expression; black, average gene expression). (B) αB-Crystallin and (C) CK5/6 expression by IHC in the same breast carcinoma that shows a basal-like gene expression and IHC profile. (D) Representative immunostaining of normal human breast tissue for αB-crystallin expression. (E) αB-Crystallin IHC of 3 representative breast carcinomas in the TMA study: strongly positive (left), weakly positive (middle), and negative (right) examples are shown. (F) Kaplan-Meier survival analysis of breast cancer–specific survival based on αB-crystallin expression. Invasive breast carcinomas were scored as positive or negative for αB-crystallin expression (left), or αB-crystallin staining was graded as weakly positive or strongly positive (right). Original magnification, ×100 (B–D), ×200 (E).