Role of IFN-γ in induction of Foxp3 and conversion of CD4⁺ CD25^– T cells to CD4⁺ Tregs
J. Clin. Invest. Zhaojun Wang, et al. 116:2434 doi:10.1172/JCI25826 [Go to this article.]

Figure 1
Severity of EAE in IFN-γ GKO and WT mice. WT (n = 27) C57BL/6 mice (IFN-γ^+/+, open circles) and IFN-γ GKO (n = 21) mice (IFN-γ^–/–, closed circles) were immunized under the same experimental conditions on day 0 with the encephalitogenic peptide of MOG (residues 35–55). Pertussis toxin (200 ng/mouse) was administered i.v. on the day of immunization and 2 days later. The mice were monitored daily and scored clinically as described in Methods. Data are representative of 3 independent experiments.