Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
J. Clin. Invest. Rajesh K. Thimmulappa, et al. 116:984 doi:10.1172/JCI25790 [Go to this article.]

Figure 4
Greater expression of proinflammatory genes associated with the innate immune response in the lungs of Nrf2-deficient mice. (A–C) Expression of cytokines (A), chemokines (B), and adhesion molecules/receptors (C) 30 minutes after nonlethal i.p. injection of LPS (60 μg per mouse) in Nrf2-deficient and wild-type mice. Gene expression data were obtained from microarray analysis. Data are represented as mean fold change obtained from comparing LPS-challenged to vehicle-treated lungs of the same genotype on a semilog scale. All the represented fold change values of LPS-treated lungs of Nrf2^–/– mice are significant compared with wild-type mice at P <0.05.