Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
J. Clin. Invest. Rajesh K. Thimmulappa, et al. 116:984 doi:10.1172/JCI25790 [Go to this article.]

Figure 3
LPS and CLP induce greater secretion of TNF-α in Nrf2-deficient mice. (A) Serum concentration of TNF-α in Nrf2^+/+ and Nrf2^–/– mice 1.5 hours after LPS injection (1.5 mg per mouse). (B) Serum concentration of TNF-α in Nrf2^+/+ and Nrf2^–/– mice 6 hours after CLP. (C) TNF-α levels in BAL fluid at 2 hours after LPS delivery by i.p. injection (60 μg per mouse) and/or intratracheal instillation (10 μg per mouse). TNF-α in the BAL fluid of vehicle-treated mice was not detectable. Data are presented as mean α SEM. *Differs from vehicle control of the same genotype. ^†Differs from LPS-treated wild-type mice. P < 0.05. ND, n detected.