Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
J. Clin. Invest. Rajesh K. Thimmulappa, et al. 116:984 doi:10.1172/JCI25790 [Go to this article.]

Figure 1
Nrf2^–/– mice were more sensitive to LPS and septic peritonitis–induced septic shock. (A and B) Mortality after LPS administration. Age-matched male Nrf2^+/+ (n = 10) and Nrf2^–/– mice (n = 10) were injected i.p. with LPS (0.75 and 1.5 mg per mouse). (C) Acute septic peritonitis was induced by CLP. CLP and sham operations were performed as described in Methods on age-matched male Nrf2^+/+ (n = 10) and Nrf2^–/– mice (n = 10). Mortality was assessed every 12 hours for 5 days. *Nrf2^+/+ mice showed improved survival compared wi Nrf2–/– mice. P < 0.05.