Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
J. Clin. Invest. Claude Knauf, et al. 115:3554 doi:10.1172/JCI25764 [
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Figure 6Central control by central GLP-1 of
ChREBP and
HKII mRNA in muscles. (
A)
ChREBP and (
B)
HKII mRNA concentrations (AU) were assessed in muscles of C57BL/6 and
MIRKO mice during hyperinsulinemic euglycemic (5.5 mM, G5) or hyperglycemic (20 mM, G20) clamps. Some hyperglycemic C57BL/6 and
MIRKO mice had Ex9 simultaneously infused into their brains. The mean of 4 mice per group is shown. *
P < 0.05 versus euglycemic WT mice.
