Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
J. Clin. Invest. Claude Knauf, et al. 115:3554 doi:10.1172/JCI25764 [
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Figure 5Central control by GLP-1 of muscle GSK3β phosphorylation. Muscle content in 46-kDa GSK3β-P in C57BL/6 mice with ACF or Ex9 infused into their brains,
GLP-1 receptor KO mice, and
MIRKO mice infused with ACF or Ex9 into their brains during a 20-mM hyperglycemic hyperinsulinemic clamp. The mean of 4 mice per group is shown. *
P < 0.05 versus ACF-infused WT mice.
