Brain glucagon-like peptide–1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
J. Clin. Invest. Claude Knauf, et al. 115:3554 doi:10.1172/JCI25764 [Go to this article.]

Figure 4
Central control by GLP-1 of whole-body GIR and muscle glycogen content are independent of muscle insulin action. (A) GIR (mg/kg/min) and (B) muscle glycogen content (mg/g) were measured in MIRKO mice infused with ACF (black bars) or Ex9 (white bars) during 20-mM hyperglycemic hyperinsulinemic conditions. The mean of 5–6 mice per group is represented. (C) PI3K activity (AU) in hind limb muscles of C57BL/6 mice infused with ACF (black bars) or Ex9 (white bars). The mean of 4 mice per group is shown. *P < 0.05 versus icv ACF-infused mice.