Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
J. Clin. Invest. Xiaocheng Dong, et al. 116:101 doi:10.1172/JCI25735 [
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Figure 3Body growth, bone mineral density, and adiposity. (
A) Growth curves were constructed by plotting of the mean ± SEM body weight of each group. *
P < 0.05 for
Irs1–/– versus
LKO::Irs1–/–; **
P < 0.001 for
Irs1–/– versus
LKO::Irs1–/–. (
B) A representative picture of 4-week-old
LKO,
Irs1–/–, and
LKO::Irs1–/– mice. (
C) The average ± SEM bone density (g/cm
2) determined by dual-energy x-ray absorptiometry scanning. (
D) Tissue weight — liver, pancreas, and perigonadal fat pad — normalized to body weight. (
E) Average ± SEM serum leptin levels for each group were determined in the random-fed mice using mouse leptin ELISA. (
F)
Igf1 mRNA levels were determined by real-time PCR in liver extracts from each group. (
G) Serum Igf1 levels (average ± SEM,
n = 6) in six 8-week-old male mice in each group were determined using a mouse Igf1 ELISA kit.
