Cardiac mast cell–derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion
J. Clin. Invest. Christina J. Mackins, et al. 116:1063 doi:10.1172/JCI25713 [
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Figure 5
Mast cell stabilization, renin inhibition, and AT
1
receptor blockade markedly reduce the occurrence of reperfusion arrhythmias in a guinea pig heart model of ischemia/reperfusion.
(
A) Percentage incidence of VT/VF in 55 hearts subjected to 20-minute global ischemia followed by 30-minute reperfusion either in the absence (
n = 15) or presence of lodoxamide (10 μM;
n = 13), cromolyn (300 μM;
n = 11), BILA2157 (100 nM;
n = 6), or EXP3174 (300 nM;
n = 10). *Significantly different from control reperfusion;
P < 0.05 by c
2 test. (
B) Representative ECG tracings from 5 of the abe hearts.
