VSIG4, a B7 family–related protein, is a negative regulator of T cell activation
J. Clin. Invest. Lorenz Vogt, et al. 116:2817 doi:10.1172/JCI25673 [Go to this article.]

Figure 6
Z39Ig, the human homolog of VSIG4, inhibits T cell proliferation. (A) Proliferation assays were performed with purified mouse CD4⁺ T cells with 0.5 μg/ml anti-CD3 in the presence or absence of 2 μg/ml anti-CD28 with Z39Ig-Ig (human VSIG4) or control IgG1 at a concentration of 5 μg/ml. (B) Proliferation assays were performed with CD4⁺ T cells purified from human PBMCs in the presence of the indicated amounts of anti-CD3 together with Z39Ig-Ig (human VSIG4) or control IgG1 at a concentration of 20 μg/ml. Error bars represent standard deviations for data from experiments performed in triplicate. Representative data from at least 2 independent similar experiments are shown. The differences between Z39Ig-Ig– treated cells compared with control IgG1–treated cells were significant (P < 0.05) in both A and B.