VSIG4, a B7 family–related protein, is a negative regulator of T cell activation
J. Clin. Invest. Lorenz Vogt, et al. 116:2817 doi:10.1172/JCI25673 [Go to this article.]

Figure 3
VSIG4 is expressed on resting tissue macrophages. Organs of untreated mice were assessed for VSIG4 expression by histology. (A and E) Kupffer cells lining the sinusoids of the liver were evenly positive for VSIG4. (B and F) Occasional macrophages of the red pulp of the spleen were positive, while macrophages of the white pulp were negative for VSIG4 (B). Within the red pulp (F), iron-laden macrophages (a weak granular signal was derived from the iron) were negative (small arrow), while other macrophages were weakly positive for VSIG4 (large arrowheads). (C and G) The myocardium showed an uneven distribution of VSIG4-positive macrophages. VSIG4 was also detected in tissue-resident macrophages of adipose tissue (D). VSIG4 was absent in thymic cortex and detected in rare macrophages of the thymic medulla (H). Representative stainings of at least 2 independent experiments are shown. Original magnification, ×60 (A–D); ×150 (E–H).