SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1–dependent inflammatory arthritis
J. Clin. Invest. Peter K.K. Wong, et al. 116:1571 doi:10.1172/JCI25660 [Go to this article.]

Figure 6
Socs3^–/Δvav T lymphocytes have markedly enhanced antigen-specific proliferation and IL-17 production in vitro. (A and B) Popliteal (A) and axillary (B) LN cells from arthritic mice were cultured with mBSA for 72 hours, and cellular proliferation was assessed by [³H]thymidine incorporation. Data are representative of 2 independent experiments. (C) Supernatants were harvested from T lymphocyte cultures after 72 hours of stimulation with mBSA and assayed for IL-17 by ELISA. IL-17 was undetectable in WT supernatants following mBSA stimulation. *P < 0.05 versus WT; **P < 0.01 versus WT and Socs3^+/Δvav.