SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1–dependent inflammatory arthritis
J. Clin. Invest. Peter K.K. Wong, et al. 116:1571 doi:10.1172/JCI25660 [
Go to this article.]
Figure 3
Accumulation of neutrophils (CD11b
+
GR-1
+
cells) in the synovium of
Socs3–/Δvav
mice during acute arthritis.
Synovium was dissected from knee joints of arthritic mice on day 7 after arthritis induction. Pooled synovial cells from 5 mice per group were isolated by enzymatic digestion and stained for expression of CD45, CD11b, and GR-1. Analysis of CD11b and GR-1 expression was performed on CD45
+ cells. Results shown are representative of 3 independent experiments. Percentages in top left and right boxes indicate the percentage of CD11b
+GR-1
– and CD11b
+GR-1
+ cells, respectively.
