A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y
J. Clin. Invest. Leigh D. Plant, et al. 116:430 doi:10.1172/JCI25618 [Go to this article.]

Figure 3
Cells expressing Y1103 channels show sustained current at a low pHi. Whole-cell currents were recorded in HEK-293 cells expressing S1103 or Y1103 channels as indicated with pipette and bath solutions (see Methods) with cells held at –100 mV and stepped to –30 mV for 100 ms at a rate of 0.5 Hz. Scale bars represent 300 pA and 20 ms. (A) Representative currents recorded from cells at the indicated pHi. (B) Ensemble averages of 500 sweeps recorded from 10 cells with the indicated channel and pHi. Late current was 5.23% ± 0.85% of peak (n = 10 cells). Peak currents were not significantly different and were –1311 ± 143 pA and 1252 ± 139 pA, for S1103 at normal and low pH, respectively, and 1267 ± 173 pA and 1195 ± 245 pA for Y1103 at normal and low pH, respectively (n = 10 cells per condition).