Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations
J. Clin. Invest. Adrienne M. Dorrance, et al. 116:2707 doi:10.1172/JCI25546 [Go to this article.]

Figure 1
Generation of Mll^PTD/WT mice. The backbone of the targeting vector is ploxPneo1 and contains a genomic clone spanning Mll intron 4 through intron 11. Linearization of the vector at a unique SfiI site within intron 4 allows for recombination at the germline intron 4 of Mll. A plasmid vector expressing Cre recombinase from a CMV promoter (pCre) was used to excise the neo cassette.