Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice
J. Clin. Invest. Varsha Kumar, et al. 116:512 doi:10.1172/JCI25536 [Go to this article.]

Figure 5
C5aR-dependent upregulation of FcγRI/RIII mRNA in Kupffer cells during AIHA. mRNA expression of FcγRI (A), FcγRIII (B), and FcRγ (C) was determined by TaqMan RT-PCR analysis of liver Kupffer cells derived from C57BL/6 WT and C5aR^–/– mice at 24 hours after injection of 34-3C mAb (black bars) as compared with mice not receiving 34-3C mAb (gray bars). Results are expressed as mean values ± SD obtained from 3–5 mice in each group. Significant differences were determined by Student’s t test (*P < 0.05; **P < 0.001).