Modulation of atherosclerosis in mice by Toll-like receptor 2
J. Clin. Invest. Adam E. Mullick, et al. 115:3149 doi:10.1172/JCI25482 [Go to this article.]

Figure 4
Measurement of aortic atherosclerosis in Pam3-exposed mice. (A) Aortic atherosclerosis expressed as a fraction of total area after 12 weeks of an HFD and weekly i.p. injections of vehicle (veh) or Pam3 in female Ldlr^–/– and Ldlr–/–Tlr2^–/– mice. (B–D) Representative aortae from Ldlr^–/– mice in the following groups: vehicle (B), 25 μg Pam3 (C), and 50 μg Pam3 (D). A dose-response effect of Pam3 administration and lesion development was observed. Profuse abdominal aortic atherosclerosis was observed in mice exposed to 50 μg Pam3. Lesion severity in TLR2-deficient animals was not affected by Pam3. Scale bar: 0.5 cm.