Synaptic activity becomes excitotoxic
in neurons exposed to elevated
levels of platelet-activating factor
J. Clin. Invest. Matthew J. Bellizzi, et al. 115:3185 doi:10.1172/JCI25444 [
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Figure 5Activity-dependent dendritic beading is delayed, long lasting, and local. Dendritic beading in a cPAF-exposed hippocampal slice developed with a delay after HFS and progressed throughout the recording trial. In addition, focal swellings were restricted to discrete regions along the dendrite with no apparent disruption of dendrite and spine morphology in intervening areas. Scale bars: 20 μm.
