TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
J. Clin. Invest. Koichi Obata, et al. 115:2393 doi:10.1172/JCI25437 [
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Figure 7Reversal of hyperalgesia to cold by a selective blockade of TRPA1 expression. (
A and
B) Pretreatment with TRPA1 AS-ODN (0.5 nmol/μl
–1/h
–1) (AS 0.50) prevents cold hyperalgesia, but not heat hyperalgesia or mechanical allodynia, induced by peripheral inflammation (
A) and injury to the L5 spinal nerve (
B). Cold and heat hyperalgesia were tested using the cold plate test and the plantar test, respectively, at days 1 and 3 after CFA injection or at days 3 and 7 after L5 SNL. Mechanical allodynia was examined using a Dynamic Plantar Aesthesiometer. Data represent mean ± SEM;
n = 8 per group.
#P < 0.05 compared with the MM-ODN (0.5 nmol/μl
–1/h
–1) (MM 0.50) group.
