Lessons learned from cancer may help in the treatment of pulmonary hypertension
J. Clin. Invest. Serge Adnot, et al. 115:1461 doi:10.1172/JCI25399 [
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Figure 1Hypothetical mechanisms leading to hyperplasia of SMCs or ECs in PAH. A number of growth stimuli may act predominantly by inducing mitogenic signals, which may then lead to survivin expression through cell cycle_dependent pathways (cells stimulated by VEGF, PDGF, etc.). Stimuli with a predominant antiapoptotic effect may act on survivin expression chiefly through cell cycle_independent pathways (cells stimulated by IL-1, angiopoietin-1 [Ang1], hypoxia, etc.). The potential effects of factors involved in the pathogenesis of PAH, such as 5-HT, ET-1, TGF-β, and BMPs are unknown.
