BLyS and APRIL in rheumatoid arthritis
J. Clin. Invest. Thorsten M. Seyler, et al. 115:3083 doi:10.1172/JCI25265 [
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Figure 9Treatment with TACI:Fc increases T cell activation in diffuse synovitis. Synovial tissues from 5 patients with diffuse synovitis were implanted into SCID mice. Chimera mice were treated with TACI:Fc and control Fc, and explanted tissue was analyzed as described in Figure
6. Neutralization of APRIL/BLyS in diffuse synovitis markedly increased IFN-γ transcripts, whereas productions of IgG
1/2, CCL19, and TNF-α mRNA were unaffected. Results are given as box plots, as described in Figure
1.
