BLyS and APRIL in rheumatoid arthritis
J. Clin. Invest. Thorsten M. Seyler, et al. 115:3083 doi:10.1172/JCI25265 [Go to this article.]

Figure 5
TACI⁺ T cells in aggregate synovitis. Four-color flow cytometry analysis was used to phenotype TACI⁺ cell populations in synovial infiltrates from patients with aggregate synovitis. Tissue-infiltrating cells were isolated from freshly harvested synovial biopsies and stained with PerCP-labeled anti-CD3 and APC-labeled anti-CD138. (A) Control stain with PE-labeled, isotype-matched Ab on CD3⁺ T cells. (B) TACI is expressed on a subset of synovial CD3⁺ T cells. (C) Expression of TACI by synovial CD138⁺ plasma cells. (D) A subset of CD20⁺ B cells is positive for TACI. Results are representative of 3 tissues with aggregate and 3 tissues with diffuse synovitis. Percentage of cells in each quandrant is indicated.