The role of cerebral amyloid β accumulation in common forms of Alzheimer disease
J. Clin. Invest. Sam Gandy, et al. 115:1121 doi:10.1172/JCI25100 [Go to this article.]

Figure 1
Different assembly (biophysical) states of Aβ. The assembled forms obtained from incubation of synthetic Aβ are highly sensitive to preparation and incubation. Widely differing proportions of insoluble fibrils (A), soluble PFs (B), and oligomers (also known as ADDLs) are revealed by atomic force microscopy. Typical PF and fibril preparations contain varying levels of small globular molecules, putatively Aβ oligomers (ADDLs). ADDL preparations (C) initiated from monomeric dimethyl sulfoxide stock solutions are fibril- and PF-free and uniquely comprise oligomers. Scale bars: 200 nm. Figure reproduced with permission from Trends in Neurosciences (8).