In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development
J. Clin. Invest. Masahiro Goto, et al. 116:953 doi:10.1172/JCI25091 [
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Figure 7Human early anterior pituitary development. (
A) Sagittal section from head at 50 dpc. Pound symbol indicates oral cavity. (
B–
D) Brightfield IHC with antibodies to ACTH (
B and
D) and GR (
C) counterstained by toluidine blue.
B and
C show higher-magnification views of boxed region in
A. Arrows show overlapping expression profiles of cytoplasmic ACTH and nuclear GR in adjacent sections. (
D) Anterior pituitary at 8 wpc. bs, basosphenoid bone; h, developing hypothalamus; rp, Rathke’s pouch; t, tongue. Scale bars: 500 μm (
A), 100 μm (
B and
C), 200 μm (D).
