In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development
J. Clin. Invest. Masahiro Goto, et al. 116:953 doi:10.1172/JCI25091 [
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Figure 3Steroidogenic enzyme and StAR expression in the developing human adrenal gland. Brightfield IHC at sequential developmental ages counterstained by toluidine blue with antibodies to StAR (
A–
E), CYP11A (
F–
J), CYP17 (
K–
O), CYP21 (
P–
T), and CYP11B1/CYP11B2 (
U–
Y). Dotted ring in
A illustrates extent of the adrenal cortex in left panels (
A,
F,
K,
P, and
U). In other images, the definitive zone (DZ) is oriented to the left and the fetal zone (FZ) to the right. At 14 wpc, these 2 zones were separated by an additional transitional zone (TZ). Scale bar: 300 μm.
