Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans
J. Clin. Invest. Ana Luiza Maia, et al. 115:2524 doi:10.1172/JCI25083 [
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Figure 3Human D1- and D2-catalyzed T
4 to T
3 conversion at different FT
4 concentrations. (
A) Fractional T
4 to T
3 conversion in whole HEK 293 cells transiently expressing D1 or D2. (
B)
Vmax estimates for D1 and D2 in cell sonicates. (
C) T
3 production in whole cells expressing D1 or D2. (
D) Ratios of the whole-cell to cell sonicate T
3 production, or catalytic efficiency, of D1 and D2 enzymes.
