Type 2 iodothyronine deiodinase is the major source of plasma T₃ in euthyroid humans
J. Clin. Invest. Ana Luiza Maia, et al. 115:2524 doi:10.1172/JCI25083 [Go to this article.]

Figure 2
Chromatographic analysis of the products of D1- and D2-catalyzed deiodination. (A) Pathway of T₄ deiodination by D1. (B and C) HEK 293 cells transfected with 100 ng of D1 or D2 were homogenized in the medium after 24 hours incubation with labeled T₄ or T₃ and the deiodination products analyzed by HPLC. (B) Chromatographic patterns of the products of D1- or D2-catalyzed [¹²⁵I]T₄ deiodination. (C) Patterns of the products of outer ring–labeled [¹²⁵I]T₃ deiodination by D1- or D2-expressing cells.