A mouse model of juvenile hemochromatosis
J. Clin. Invest. Franklin W. Huang, et al. 115:2187 doi:10.1172/JCI25049 [
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Figure 4Increased ferroportin expression in
Hjv–/– mice. Ferroportin expression was detected by immunohistochemistry. (
A and
C) Wild-type proximal duodenum and (
B and
D)
Hjv–/– proximal duodenum, approximately 0.5 cm from the pylorus, which is shown on the right in
A and
B. Staining is most intense proximally in the wild-type animals but is expressed more intensely and along the distal two-thirds of the villus in the mutant animals. (
E) Wild-type liver. (
F)
Hjv–/– liver. (
G) Wild-type spleen. (
H)
Hjv–/– spleen. Note the intense Kupffer cell and macrophage staining in the
Hjv–/– liver (
F) and spleen (
H). Original magnification, ×20 (
A and
B), ×100 (
C,
D,
G, and
H), and ×400 (
E and
F).
