Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin
J. Clin. Invest. Peter C. Minneci, et al. 115:3409 doi:10.1172/JCI25040 [Go to this article.]

Figure 3
Effects of hemolysis and inhaled NO on MAP. In paired experiments, all animals received a 6-hour D5W infusion during the baseline study and 1 week later were randomized to a 6-hour intervention study of either D5W, D5W plus NO, free water, or free water plus NO. Changes in MAP over the course of the 6-hour baseline (filled circles) and intervention studies (open circles) are shown. In all 4 groups of animals, there were statistically similar small increases in MAP during the 6-hour baseline D5W infusion. Compared with an equivalent infusion of D5W with or without NO (nonhemolyzing control groups), free water–induced intravascular hemolysis caused a significant increase in MAP, which was attenuated by the concurrent inhalation of NO gas (P = 0.0003 for interaction of NO and hemolysis).