Reversal of experimental pulmonary hypertension by PDGF inhibition
J. Clin. Invest. Ralph Theo Schermuly, et al. 115:2811 doi:10.1172/JCI24838 [
Go to this article.]
Figure 6Increased PDGFRβ expression/phosphorylation in MCT-induced pulmonary hypertension. Western blot analysis was used to assess expression of PDGFRβ and PDGFRβ phosphorylation (P-PDGFRβ) in rat lungs from controls and animals treated with MCT (14 days), MCT (28 days), MCT (42 days), and MCT (42 days)/STI571. Immunoblots are representative of 4 individual lungs from each group, showing identical results. Quantification of PDGFRβ and PDGFRβ phosphorylation is shown in the bar graphs. PDGFRβ and PDGFRβ phosphorylation are normalized to GAPDH. *
P < 0.05 versus control;
†P < 0.05 versus MCT at day 28;
‡P < 0.05 versus MCT at day 42.
