Reversal of experimental pulmonary hypertension by PDGF inhibition
J. Clin. Invest. Ralph Theo Schermuly, et al. 115:2811 doi:10.1172/JCI24838 [
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Figure 2Effects of STI571 on right heart hypertrophy and survival. Ratio of RV to LV plus septum weight (RV/LV+S) (
A) and survival rates of STI571-treated versus sham-treated (MCT control; filled circles) animals (
B) are shown. Treatment at doses of 1, 10, and 50 mg/kg/d was started at day 28 after MCT injection; the different doses are indicated. (
C) RV/LV+S values of chronically hypoxic mice. STI571 was applied at doses of 50 and 100 mg/kg/d by gavage from day 21–35. *
P < 0.05 versus control;
†P < 0.05 versus MCT at day 28 or hypoxia at day 21;
‡P < 0.05 versus MCT at day 42 or hypoxia at day 35.
