A frameshift polymorphism in P2X5
elicits an allogeneic cytotoxic T lymphocyte response associated with remission
of chronic myeloid leukemia
J. Clin. Invest. Björn de Rijke, et al. 115:3506 doi:10.1172/JCI24832 [
Go to this article.]
Figure 2The LRH-1 locus is closely linked to a cluster of markers on chromosome 17p13.2. (
A) LRH-1 segregation pattern for individuals of the CEPH pedigrees 1331, 1332, 1347, 1413, 1362, and 102. EBV-LCLs of all available family members were transduced with HLA-B*0702 and tested for recognition by CTL RP1. Filled circles (females) or squares (males) represent individuals scored as positive for the LRH-1 phenotype, and open circles (females) or squares (males) represent individuals scored as negative. Shaded symbols represent individuals from whom no EBV-LCLs was available. (
B) Genetic map of chromosome 17p13.2 showing relative marker loci oriented with the centromere at the bottom of the figure. lod scores summed for all available families used in the linkage analysis are shown to the right of each genomic marker. CEPH families that are not genotyped for a particular marker and therefore not included in the linkage analysis are indicated in parentheses.
