Tonsillar homing of Epstein-Barr virus–specific CD8+ T cells and the virus-host balance
J. Clin. Invest. Andrew D. Hislop, et al. 115:2546 doi:10.1172/JCI24810 [Go to this article.]

Figure 3
Summary of the frequency of EBV-specific responses in the PBMCs and tonsils of 6 IM, 2 post-IM, and 11 long-term carrier tonsillectomy patients; symbols connected by a line refer to a particular epitope-specific response in an individual donor. (A) Percentage of CD8⁺ T cells staining with EBV lytic epitope–specific tetramers in IM (left panel) and post-IM (middle panel) patients and long-term carriers (right panel). (B) Percentage of CD8⁺ T cells staining with EBV latent epitope–specific tetramers in IM (left panel) and post-IM (middle panel) patients and long-term carriers (right panel). P values shown were obtained using linear mixed model analysis as described in Methods. Significant differences are indicated by an asterisk. In addition, in acute IM, the reduction in epitope-specific T cell representation in tonsil relative to blood was significantly greater for lytic than for latent reactivities (P = 0.004); also, in carriers, the increase in epitope-specific T cell representation in tonsil relative to blood was significantly greater for latent than for lytic epitopes (P = 0.003).